Adapalene

Modify Date: 2024-01-02 15:34:28

Adapalene Structure
Adapalene structure
 Common Name Adapalene
CAS Number 106685-40-9 Molecular Weight 412.520
Density 1.2±0.1 g/cm3 Boiling Point 606.3±55.0 °C at 760 mmHg
Molecular Formula C28H28O3 Melting Point 319-322ºC
MSDS Chinese USA Flash Point 205.9±25.0 °C

 Use of Adapalene


Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher thanadapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].

 Names

Name adapalene
Synonym More Synonyms

 Adapalene Biological Activity

Description Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher thanadapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].
Related Catalog
References

[1]. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7.

[2]. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 606.3±55.0 °C at 760 mmHg
Melting Point 319-322ºC
Molecular Formula C28H28O3
Molecular Weight 412.520
Flash Point 205.9±25.0 °C
Exact Mass 412.203857
PSA 46.53000
LogP 8.04
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.655
Storage condition Store at +4°C

 Safety Information

Hazard Statements H413
RIDADR NONH for all modes of transport
HS Code 2918990090

 Synthetic Route

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles29

More Articles
Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream.

Eur. J. Pharm. Biopharm. 88(3) , 614-24, (2015)

A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion as a topical drug delivery system (TDDS) for follicular penetration has been introduced. The objective of the present study was to ...
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.

Mol. Cancer 14(1) , 204, (2015)

An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell ca...
Origins of the breast milk-derived cells; an endeavor to find the cell sources.

Cell Biol. Int. 39(5) , 611-8, (2015)

Fresh human breast milk consists of a heterogeneous population of cells that may offer a non-invasive source of cells for therapeutic proposes. The aims of this study were to characterize the breast m...

 Synonyms

Adapalene
CD-271
Adapalenum
Differin
6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid
2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo[3.3.1.1]dec-1-ylphenyl)-
6-[3-(Adamantan-1-yl)-4-methoxyphenyl]-2-naphthoic acid
Adapaleno
Adaferin
MFCD03106112
Differine
6-(4-methoxy-3-tricyclo[3.3.1.1]dec-1-ylphenyl)naphthalene-2-carboxylic acid
6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
6-[4-methoxy-3-(tricyclo[3.3.1.1]dec-1-yl)phenyl]naphthalene-2-carboxylic acid
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  • Product Name: Adapalene
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  • Purity: 98.0%
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Related Compounds: More...
Adapalene-d3
1276433-89-6
Adapalene impurity C
43109-77-9
Adapalene Glucuronide
359699-07-3
O-Desmethyl Adapalene
125316-60-1
Adapalene Methyl Ester
106685-41-0
Adapalene (sodium salt)
911110-93-5
Adapalene-d6 Methyl Ester
1330264-23-7
Adapalene / benzoyl peroxide
1194805-81-6
Chemsrc provides Adapalene(CAS#:106685-40-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Adapalene are included as well.>> amp version: Adapalene

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