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  • Product Name: Adapalene
  • Price: $250.0/100mg $500.0/250mg $1000.0/1g
  • Purity: 98.0%
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Related CAS#:
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106685-40-9

106685-40-9 structure
106685-40-9 structure
  • Name: Adapalene
  • Chemical Name: adapalene
  • CAS Number: 106685-40-9
  • Molecular Formula: C28H28O3
  • Molecular Weight: 412.520
  • Catalog: API Special medicine Dermatology medication
  • Create Date: 2018-07-30 12:11:16
  • Modify Date: 2024-01-02 15:34:28
  • Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher thanadapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].
Name adapalene
Synonyms Adapalene
CD-271
Adapalenum
Differin
6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid
2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo[3.3.1.1]dec-1-ylphenyl)-
6-[3-(Adamantan-1-yl)-4-methoxyphenyl]-2-naphthoic acid
Adapaleno
Adaferin
MFCD03106112
Differine
6-(4-methoxy-3-tricyclo[3.3.1.1]dec-1-ylphenyl)naphthalene-2-carboxylic acid
6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
6-[4-methoxy-3-(tricyclo[3.3.1.1]dec-1-yl)phenyl]naphthalene-2-carboxylic acid
Description Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher thanadapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].
Related Catalog
References

[1]. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7.

[2]. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.
Density 1.2±0.1 g/cm3
Boiling Point 606.3±55.0 °C at 760 mmHg
Melting Point 319-322ºC
Molecular Formula C28H28O3
Molecular Weight 412.520
Flash Point 205.9±25.0 °C
Exact Mass 412.203857
PSA 46.53000
LogP 8.04
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.655
Storage condition Store at +4°C
Hazard Statements H413
RIDADR NONH for all modes of transport
HS Code 2918990090
HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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