PD 119819
Modify Date: 2024-01-15 20:36:08
PD 119819 structure
|
Common Name | PD 119819 | ||
|---|---|---|---|---|
| CAS Number | 105277-43-8 | Molecular Weight | 365.42600 | |
| Density | N/A | Boiling Point | 575.7ºC at 760 mmHg | |
| Molecular Formula | C21H23N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 302ºC | |
Use of PD 119819PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2]. |
| Name | 7-[3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]chromen-4-one |
|---|
| Description | PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Dopamine Receptor |
| In Vivo | PD 119819 (5~80 mg/kg; nasogastric intubation) makes monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values is evident after doses of 80 mg/kg[1]. Animal Model: Cynomolgus monkey[1] Dosage: 5~80 mg/kg Administration: Nasogastric intubation Result: Made monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values were evident after doses of 80 mg/kg. |
| References |
| Boiling Point | 575.7ºC at 760 mmHg |
|---|---|
| Molecular Formula | C21H23N3O3 |
| Molecular Weight | 365.42600 |
| Flash Point | 302ºC |
| Exact Mass | 365.17400 |
| PSA | 58.81000 |
| LogP | 2.78200 |
| Vapour Pressure | 2.96E-13mmHg at 25°C |