105277-43-8

105277-43-8 structure

Name: PD 119819
Chemical Name: 7-[3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]chromen-4-one
CAS Number: 105277-43-8
Molecular Formula: C₂₁H₂₃N₃O₃
Molecular Weight: 365.42600
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2016-08-24 06:28:51
Modify Date: 2024-01-15 20:36:08
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2].

Name	7-[3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]chromen-4-one

Description	PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine Receptor
In Vivo	PD 119819 (5~80 mg/kg; nasogastric intubation) makes monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values is evident after doses of 80 mg/kg[1]. Animal Model: Cynomolgus monkey[1] Dosage: 5~80 mg/kg Administration: Nasogastric intubation Result: Made monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values were evident after doses of 80 mg/kg.
References	[1]. Macallum GE, et al. Renal and hepatic toxicity of a benzopyran-4-one in the Cynomolgus monkey. Toxicology. 1989;59(1):97-108. [2]. Jaen JC, et al. Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. J Med Chem. 1991;34(1):248-256.