Targapremir 210

Modify Date: 2024-01-02 03:25:21

Targapremir 210 Structure
Targapremir 210 structure
Common Name Targapremir 210
CAS Number 1049722-30-6 Molecular Weight 592.694
Density N/A Boiling Point N/A
Molecular Formula C32H36N10O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Targapremir 210


Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.

 Names

Name Targapremir-210
Synonym More Synonyms

 Targapremir 210 Biological Activity

Description Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.
Related Catalog
Target

IC50: 200 nM for MDA-MB-231 cells [1].

References

[1]. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455.

 Chemical & Physical Properties

Molecular Formula C32H36N10O2
Molecular Weight 592.694
Exact Mass 592.302246
LogP 3.59

 Synonyms

N-(3-Azidopropyl)-4-(3-(6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanamide
Butanamide, N-(3-azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]-
N-(3-Azidopropyl)-4-{3-[5-(4-methyl-1-piperazinyl)-1H,1'H-2,5'-bibenzimidazol-2'-yl]phenoxy}butanamide