1049722-30-6

1049722-30-6 structure

Name: Targapremir 210
Chemical Name: Targapremir-210
CAS Number: 1049722-30-6
Molecular Formula: C₃₂H₃₆N₁₀O₂
Molecular Weight: 592.694
Catalog: Signaling Pathways Epigenetics MicroRNA
Create Date: 2018-08-11 14:21:28
Modify Date: 2024-01-02 03:25:21
Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.

Name	Targapremir-210
Synonyms	N-(3-Azidopropyl)-4-(3-(6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanamide Butanamide, N-(3-azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]- N-(3-Azidopropyl)-4-{3-[5-(4-methyl-1-piperazinyl)-1H,1'H-2,5'-bibenzimidazol-2'-yl]phenoxy}butanamide

Description	Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.
Related Catalog	Signaling Pathways >> Epigenetics >> MicroRNA Research Areas >> Cancer
Target	IC50: 200 nM for MDA-MB-231 cells [1].
References	[1]. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455.