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Targapremir 210

Names

[ CAS No. ]:
1049722-30-6

[ Name ]:
Targapremir 210

[Synonym ]:
N-(3-Azidopropyl)-4-(3-(6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanamide
Butanamide, N-(3-azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]-
N-(3-Azidopropyl)-4-{3-[5-(4-methyl-1-piperazinyl)-1H,1'H-2,5'-bibenzimidazol-2'-yl]phenoxy}butanamide

Biological Activity

[Description]:

Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> MicroRNA
Research Areas >> Cancer

[Target]

IC50: 200 nM for MDA-MB-231 cells [1].


[References]

[1]. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455.


[Related Small Molecules]

MIR96-IN-1 | SID 3712249 | Lin28-let-7a antagonist 1

Chemical & Physical Properties

[ Molecular Formula ]:
C32H36N10O2

[ Molecular Weight ]:
592.694

[ Exact Mass ]:
592.302246

[ LogP ]:
3.59

Related Compounds