A1AR antagonist 4

Modify Date: 2025-08-24 18:37:56

Use of A1AR antagonist 4

A1AR antagonist 4 (compound 22) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.51 and a pKi of 6.29[1].

Name	A1AR antagonist 4

Description	A1AR antagonist 4 (compound 22) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.51 and a pKi of 6.29[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	hA1AR:6.29 (pKi) hA2AAR:<4 (pKi)
References	[1]. Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936.

Molecular Formula	C₂₃H₂₅N₃O₂
Molecular Weight	375.46