A01

Modify Date: 2024-01-07 00:23:27

A01 Structure
A01 structure
Common Name A01
CAS Number 1007647-73-5 Molecular Weight 512.93
Density 1.5±0.1 g/cm3 Boiling Point 642.3±65.0 °C at 760 mmHg
Molecular Formula C22H20ClF3N4O3S Melting Point N/A
MSDS Chinese USA Flash Point 342.2±34.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of A01


Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1].

 Names

Name (4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
Synonym More Synonyms

 A01 Biological Activity

Description Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1].
Related Catalog
Target

Kd: 3.664 nM (Smurf1)[1]

References

[1]. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 642.3±65.0 °C at 760 mmHg
Molecular Formula C22H20ClF3N4O3S
Molecular Weight 512.93
Flash Point 342.2±34.3 °C
Exact Mass 512.089661
LogP 3.87
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.627
Storage condition 2-8℃

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
RIDADR NONH for all modes of transport

 Synonyms

(4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
Methanone, [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-
MFCD09320899
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Price: ¥1016/10 mM * 1 mL in DMSO

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