A01

Names

[ Name ]:
A01

[Synonym ]:
(4-{[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)[4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
Methanone, [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-
MFCD09320899

Biological Activity

[Description]:

Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

Kd: 3.664 nM (Smurf1)[1]

[References]

[1]. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
642.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₀ClF₃N₄O₃S

[ Molecular Weight ]:
512.93

[ Flash Point ]:
342.2±34.3 °C

[ Exact Mass ]:
512.089661

[ LogP ]:
3.87

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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