1225580-94-8

1225580-94-8 structure
1225580-94-8 structure
  • Name: Acamprosate-d3 (calcium salt)
  • Chemical Name: calcium,3-[(2,2,2-trideuterioacetyl)amino]propane-1-sulfonate
  • CAS Number: 1225580-94-8
  • Molecular Formula: C5H7CaD3NO4S
  • Molecular Weight: 223.29900
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2017-03-24 04:17:14
  • Modify Date: 2025-08-26 20:59:42
  • Acamprosate D3 calcium is the deuterium labeled Acamprosate calcium. Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems[1][2].

Name calcium,3-[(2,2,2-trideuterioacetyl)amino]propane-1-sulfonate
Synonyms [2H3]-Acamprosate calcium salt
1-Propanesulfonic acid,3-(acetyl-2,2,2-d3-amino)-,calcium salt (2:1)
Description Acamprosate D3 calcium is the deuterium labeled Acamprosate calcium. Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Preuss UW. Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.).Alcohol Clin Exp Res. 2012 Jun;36(6):967-9. doi: 10.1111/j.1530-0277.2012.01827.x.

[3]. Witkiewitz K, Saville K, Hamreus K.Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility.Ther Clin Risk Manag. 2012;8:45-53.

[4]. Gahr M, et al. Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15.

[5]. Palucha-Poniewiera A, Pilc A.Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):102-6.

[6]. Hinton DJ, et al. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.Neuropharmacology. 2012 Jun;62(8):2480-8.

Molecular Formula C5H7CaD3NO4S
Molecular Weight 223.29900
Exact Mass 223.01400
PSA 98.17000
LogP 1.19400
Storage condition 2-8°C
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