77337-73-6
77337-73-6 structure
- Name: Acamprosate calcium
- Chemical Name: acamprosate calcium
- CAS Number: 77337-73-6
- Molecular Formula: C5H10NO4S.1/2Ca
- Molecular Weight: 200.24
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-08-22 15:24:15
- Modify Date: 2024-01-03 13:03:43
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Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.IC50 value:Target: GABA receptorAcamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In comparison with naltrexone and disulfiram, which are the other FDA-approved treatments for alcohol dependence, acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol.
| Name | acamprosate calcium |
|---|---|
| Synonyms |
Campral
Acamprosate calcium MFCD00886588 calcium acetylhomotaurinate Calciumbis[3-(acetylamino)propan-1-sulfonat] CA-Aota Alcomed 3-(Acetylamino)-1-propanesulfonic Acid Calcium Salt (2:1) Sobriol 1-Propanesulfonic acid, 3-(acetylamino)-, calcium salt (2:1) Calcium bis(3-acetamido-1-propanesulfonate) Calcium Bisacetyl Homotaurine bis[3-(acétylamino)propane-1-sulfonate] de calcium Aotal calcium acetyl homotaurinate calcium bis[3-(acetylamino)propane-1-sulfonate] calcium,3-acetamidopropane-1-sulfonate EINECS 278-665-3 Calcium bis(3-acetamidopropane-1-sulfonate) Acamprosate (calcium) |
| Description | Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.IC50 value:Target: GABA receptorAcamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In comparison with naltrexone and disulfiram, which are the other FDA-approved treatments for alcohol dependence, acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol. |
|---|---|
| Related Catalog | |
| References |
| Melting Point | >300ºC |
|---|---|
| Molecular Formula | C5H10NO4S.1/2Ca |
| Molecular Weight | 200.24 |
| PSA | 189.36000 |
| LogP | 1.05900 |
| Storage condition | Room temp |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36/37/39-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2924199090 |
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |