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Shanghai Jizhi Biochemical Technology Co., Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
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Zhejiang Hangyu API Co., Ltd
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498-02-2

498-02-2 structure

498-02-2 structure

Name: Acetovanillone
Chemical Name: apocynin
CAS Number: 498-02-2
Molecular Formula: C₉H₁₀O₃
Molecular Weight: 166.174
Catalog: Biochemical Amino acids and their derivatives FMOC-amino acid
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-02 14:07:37
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM.

Name	apocynin
Synonyms	4'-hydroxy-3'-methoxyacetophenone MFCD00008747 Acetovanillone Apocynin Ethanone, 1-(4-hydroxy-3-methoxyphenyl)- 1-(4-Hydroxy-3-methoxyphenyl)ethanone EINECS 207-854-5

Description	Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM.
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References	[1]. Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102. [2]. Stefanska J, et al. Mediators Inflamm, 2008, 106507. [3]. Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81(5):636-48.

Density	1.2±0.1 g/cm3
Boiling Point	297.5±0.0 °C at 760 mmHg
Melting Point	112-115 °C(lit.)
Molecular Formula	C₉H₁₀O₃
Molecular Weight	166.174
Flash Point	125.5±15.8 °C
Exact Mass	166.062988
PSA	46.53000
LogP	1.39
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.538
Storage condition	Refrigerator
Water Solubility	soluble in hot water

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM8800000

CHEMICAL NAME :: Acetophenone, 4'-hydroxy-3'-methoxy-

CAS REGISTRY NUMBER :: 498-02-2

BEILSTEIN REFERENCE NO. :: 0637373

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H10-O3

MOLECULAR WEIGHT :: 166.19

WISWESSER LINE NOTATION :: 1VR DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 400 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 119,273,1983

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	AM8800000
HS Code	2942000000

Precursor 7
613-70-7 132255-78-8 2480-86-6 1131-62-0
91-16-7 75-36-5 7382-68-5
DownStream 9
1031702-80-3 54771-60-7 7404-35-5 141243-23-4
25878-60-8 144735-54-6 143418-77-3 21092-94-4
18256-48-9

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%