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94-63-3 23031-36-9
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94-63-3

94-63-3 structure
94-63-3 structure
  • Name: Pralidoxime Iodide
  • Chemical Name: pralidoxime iodide
  • CAS Number: 94-63-3
  • Molecular Formula: C7H9IN2O
  • Molecular Weight: 264.064
  • Catalog: API Special medicine Antidote
  • Create Date: 2018-09-06 22:28:32
  • Modify Date: 2024-01-06 16:16:57
  • Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].
Name pralidoxime iodide
Synonyms 2-Pyridinealdoxime methiodide
2-hydroxyiminomethyl-1-methylpyridinium iodide
protopamiodide
EINECS 202-349-6
1-methyl-2-hydroxyiminomethylpyridinium iodide
Pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, iodide (1:1)
pralidoximemethiodide
PRALIDOXIMELODIDE
PYRIDINE-2-CARBOXALDOXIME METHIODIDE
PRALIDOXIME IODIDE
MFCD00011982
pyridin-2-aldoxin
p-2-am
2-PAM
2-pamiodide
2-[(E)-(Hydroxyimino)methyl]-1-methylpyridinium iodide
2-[(hydroxyimino)methyl]-1-methylpyridinium iodide
Description Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].
Related Catalog
In Vivo Pralidoxime iodide (10-150 mg/kg; i.m.) reverses paraoxon-induced respiratory toxicity in mice[3]. Animal Model: Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3] Dosage: 10, 50, 100 and 150 mg/kg Administration: Intramuscularly Result: Reversal of diethylparaoxon-induced respiratory toxicity at 150 mg/kg.
References

[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141.

[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111.

[3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138.
Density 1.7439 g/ml
Melting Point 220 °C (dec.)(lit.)
Molecular Formula C7H9IN2O
Molecular Weight 264.064
Exact Mass 263.975952
PSA 36.47000
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU4375000
CHEMICAL NAME :
Pyridinium, 2-formyl-1-methyl-, iodide, oxime
CAS REGISTRY NUMBER :
94-63-3
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C7-H9-N2-O.I
MOLECULAR WEIGHT :
264.08
WISWESSER LINE NOTATION :
T6KJ A1 B1UNQ &Q &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
305 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 13,202,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,31,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
249 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,31,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
136 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 60,261,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 5,21,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 132,50,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,5,1964 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 166,1834,1958 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 50,475,1971
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UU4375000
3784-97-2 structure

3784-97-2

~%

94-63-3 structure

94-63-3
Literature: Bioorganic and Medicinal Chemistry, , vol. 21, # 18 p. 5923 - 5930
873-69-8 structure

873-69-8
74-88-4 structure

74-88-4

~79%

94-63-3 structure

94-63-3
Literature: Hampl, Frantisek; Mazac, Jiri; Liska, Frantisek; Spogl, Jiri; Kabrt, Lubomir; Suchanek, Miloslav Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 5 p. 883 - 893
1121-60-4 structure

1121-60-4

~%

94-63-3 structure

94-63-3
Literature: Journal of the American Chemical Society, , vol. 79, p. 481,483

Chemsrc provides CAS#:94-63-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 94-63-3 | Chemsrc address: https://www.chemsrc.com/en/baike/690131.html

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