Pralidoxime Iodide structure
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Common Name | Pralidoxime Iodide | ||
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CAS Number | 94-63-3 | Molecular Weight | 264.064 | |
Density | 1.7439 g/ml | Boiling Point | N/A | |
Molecular Formula | C7H9IN2O | Melting Point | 220 °C (dec.)(lit.) | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Pralidoxime IodidePralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2]. |
Name | pralidoxime iodide |
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Synonym | More Synonyms |
Description | Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2]. |
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Related Catalog | |
In Vivo | Pralidoxime iodide (10-150 mg/kg; i.m.) reverses paraoxon-induced respiratory toxicity in mice[3]. Animal Model: Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3] Dosage: 10, 50, 100 and 150 mg/kg Administration: Intramuscularly Result: Reversal of diethylparaoxon-induced respiratory toxicity at 150 mg/kg. |
References |
[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. |
Density | 1.7439 g/ml |
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Melting Point | 220 °C (dec.)(lit.) |
Molecular Formula | C7H9IN2O |
Molecular Weight | 264.064 |
Exact Mass | 263.975952 |
PSA | 36.47000 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22 |
Safety Phrases | S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | UU4375000 |
~% Pralidoxime Iodide CAS#:94-63-3 |
Literature: Bioorganic and Medicinal Chemistry, , vol. 21, # 18 p. 5923 - 5930 |
~79% Pralidoxime Iodide CAS#:94-63-3 |
Literature: Hampl, Frantisek; Mazac, Jiri; Liska, Frantisek; Spogl, Jiri; Kabrt, Lubomir; Suchanek, Miloslav Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 5 p. 883 - 893 |
~% Pralidoxime Iodide CAS#:94-63-3 |
Literature: Journal of the American Chemical Society, , vol. 79, p. 481,483 |
A trivalent approach for determining in vitro toxicology: Examination of oxime K027.
J. Appl. Toxicol. 35(2) , 219-27, (2014) Unforeseen toxic effects contribute to compound attrition during preclinical evaluation and clinical trials. Consequently, there is a need to correlate in vitro toxicity to in vivo and clinical outcom... |
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Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications.
Toxicol. Lett. 231(1) , 92-8, (2014) Highly toxic organophosphorus (OP) nerve agents are well characterized regarding chemical, biological and toxicological properties and the effectiveness of standard atropine and oxime therapy. Open li... |
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An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.
J. Biomol. Screen. 18(1) , 108-15, (2013) Organophosphates are a class of highly toxic chemicals that includes many pesticides and chemical weapons. Exposure to organophosphates, either through accidents or acts of terrorism, poses a signific... |
2-Pyridinealdoxime methiodide |
2-hydroxyiminomethyl-1-methylpyridinium iodide |
protopamiodide |
EINECS 202-349-6 |
1-methyl-2-hydroxyiminomethylpyridinium iodide |
Pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, iodide (1:1) |
pralidoximemethiodide |
PRALIDOXIMELODIDE |
PYRIDINE-2-CARBOXALDOXIME METHIODIDE |
PRALIDOXIME IODIDE |
MFCD00011982 |
pyridin-2-aldoxin |
p-2-am |
2-PAM |
2-pamiodide |
2-[(E)-(Hydroxyimino)methyl]-1-methylpyridinium iodide |
2-[(hydroxyimino)methyl]-1-methylpyridinium iodide |