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  • DC Chemicals Limited
  • China
  • Product Name: U-104
  • Price: $300.0/100mg $600.0/250mg $1200.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

178606-66-1

178606-66-1 structure
178606-66-1 structure
  • Name: U-104
  • Chemical Name: 4-{[(4'-fluorophenyl)carbamoyl]amino}benzenesulfonamide
  • CAS Number: 178606-66-1
  • Molecular Formula: C13H12FN3O3S
  • Molecular Weight: 309.316
  • Catalog: Biochemical Inhibitor Metabolism Carbonic Anhydrase Inhibitor
  • Create Date: 2018-12-15 12:42:29
  • Modify Date: 2024-01-04 21:08:48
  • U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM; low inhibition for CA I and CA II.IC50 value: 45.1 nM/4.5 nM(Ki, CA IX/CA XII) [1]Target: Carbonic anhydrase inhibitorin vitro: U-104 (50 μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells [2]. in vivo: U-104 (38 mg/kg) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg) inhibits metastases formation in the 4T1 experimental metastasis mice model [1]. U-104 (38 mg/kg) significantly delay primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (5 mg/mL, oral gavage) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells [2].

Name 4-{[(4'-fluorophenyl)carbamoyl]amino}benzenesulfonamide
Synonyms Benzenesulfonamide, 4-[[[(4-fluorophenyl)amino]carbonyl]amino]-
Benzenesulfonamide (4-[[[(4-fluorophenyl)amino]carbonyl]amino]
4-{[(4-Fluorophenyl)carbamoyl]amino}benzenesulfonamide
4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide
Carbonic Anhydrase IX/XII Inhibitor II(U-104)
U-104
Description U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM; low inhibition for CA I and CA II.IC50 value: 45.1 nM/4.5 nM(Ki, CA IX/CA XII) [1]Target: Carbonic anhydrase inhibitorin vitro: U-104 (50 μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells [2]. in vivo: U-104 (38 mg/kg) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg) inhibits metastases formation in the 4T1 experimental metastasis mice model [1]. U-104 (38 mg/kg) significantly delay primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (5 mg/mL, oral gavage) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells [2].
Related Catalog
References

[1]. Lou Y, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71(9):3364-76.

[2]. Lock FE, et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 2013 Oct 31;32(44):5210-9.

Density 1.5±0.1 g/cm3
Melting Point 242-243℃
Molecular Formula C13H12FN3O3S
Molecular Weight 309.316
Exact Mass 309.058350
PSA 109.67000
LogP 2.12
Appearance white to beige
Index of Refraction 1.673
Storage condition 2-8°C
Water Solubility DMSO: >15mg/mL
Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26
RIDADR NONH for all modes of transport