Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Inosine,6-S-methyl-6-thio-
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Purity: 98.0%
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342-69-8

342-69-8 structure

Name: Inosine,6-S-methyl-6-thio-
Chemical Name: 6-methylthioinosine
CAS Number: 342-69-8
Molecular Formula: C₁₁H₁₄N₄O₄S
Molecular Weight: 298.32
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-07-11 11:57:39
Modify Date: 2025-08-26 16:45:03
6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	6-methylthioinosine
Synonyms	EINECS 206-442-2 6-MethylmercaptopurineRiboside MFCD00022826 6-Methylthioinosine METHYLTHIOINOSINE 6-Methylmercaptopurinribosid 6-methylmp-riboside 6-MMPR 6-METHYLTHIOPURINE RIBOSIDE 6-Methylmercaptopurine riboside

Description	6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.85g/cm3
Boiling Point	636.3ºC at 760mmHg
Melting Point	166°C
Molecular Formula	C₁₁H₁₄N₄O₄S
Molecular Weight	298.32
Flash Point	338.6ºC
Exact Mass	298.07400
PSA	138.82000
Index of Refraction	1.822
Storage condition	−20°C
Stability	Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8985000

CHEMICAL NAME :: 9H-Purine, 6-(methylthio)-9-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 342-69-8

BEILSTEIN REFERENCE NO. :: 0042871

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C11-H14-N4-O4-S

MOLECULAR WEIGHT :: 298.35

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IS1 D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 137 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 65 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 3 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,1587,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UO8985000
HS Code	29349990

Precursor 9
5188-07-8 7387-57-7 58-61-7 163632-54-0
66782-10-3 74-88-4 6974-32-9 50-66-8
73237-86-2
DownStream 9
50-66-8 18646-11-2 4338-47-0 58-61-7
23526-11-6 42021-78-3 132154-36-0 4542-23-8
53665-01-3

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342-69-8	61468-77-7
42021-83-0	67055-84-9
23526-11-6	25840-36-2
502463-37-8	51464-82-5
6165-03-3	13153-19-0
1805997-46-9	1227515-20-9
1805277-63-7	1804699-86-2
1804907-88-7	1806938-40-8
1806004-52-3	1805523-74-3
1805054-84-5	1804842-52-1