4338-47-0
4338-47-0 structure
- Name: Kinetin riboside
- Chemical Name: kinetin riboside
- CAS Number: 4338-47-0
- Molecular Formula: C15H17N5O5
- Molecular Weight: 347.326
- Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
- Create Date: 2018-06-30 02:11:23
- Modify Date: 2025-08-20 11:25:00
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Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.
| Name | kinetin riboside |
|---|---|
| Synonyms |
9H-Purin-6-amine, N-(2-furanylmethyl)-9-pentofuranosyl-
N-(2-Furylmethyl)-9-pentofuranosyl-9H-purin-6-amine furfuryladenosine EINECS 224-389-3 6-Furfurylaminopurine riboside (N6-(2-Furanylmethyl)adenosine Kinetin-9-riboside MFCD00037987 n-furfuryl-adenosin Ribosylkinetin N-Furfuryladenosine |
| Description | Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.5 μM (HCT-15 cells)[1] |
| In Vitro | Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC50=2.5 μM)[1]. Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure[2]. |
| In Vivo | Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg[2]. |
| Cell Assay | HeLa and mouse melanoma B16F-10 cells are treated with 5, 10, 20 μM kinetin riboside for 48 h. 15 μL of MTT solution (5 mg/mL) is added to each well and cells are maintained for 4 h at 37°C. Hundred microlitres of solubilizing solution is then added. After an overnight incubation at room temperature, absorbance at 490 nm is measured[2]. |
| Animal Admin | Mice: Male C57BL/6 mice are injected B16 F-10 cells. After 5 days for tumor growth, kinetin riboside (10, 20, 40 mg/kg) is injected to tumor mass directly. Drug injection is performed once a 3 days for three times. After third injection of drug, mice are kept for 3 days with no injection and tumor mass is removed from each mouse and weighed[2]. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 683.7±65.0 °C at 760 mmHg |
| Melting Point | 152-154ºC |
| Molecular Formula | C15H17N5O5 |
| Molecular Weight | 347.326 |
| Flash Point | 367.3±34.3 °C |
| Exact Mass | 347.122955 |
| PSA | 138.69000 |
| LogP | 0.20 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.798 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU7400200 |
| HS Code | 29349990 |
| Precursor 9 | |
|---|---|
| DownStream 2 | |
![[5-(6-acetamidopurin-9-yl)-3,4-diacetyloxy-oxolan-2-yl]methyl acetate structure](https://image.chemsrc.com/caspic/032/7387-58-8.png)
