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96750-66-2

96750-66-2 structure
96750-66-2 structure
  • Name: Chlorisondamine diiodide
  • Chemical Name: trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-1,3-dihydroisoindol-2-ium-2-yl)ethyl]azanium,diiodide
  • CAS Number: 96750-66-2
  • Molecular Formula: C14H20Cl4I2N2
  • Molecular Weight: 611.94
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
  • Create Date: 2017-12-04 01:54:38
  • Modify Date: 2024-01-04 16:18:05
  • Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way[1].
Name trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-1,3-dihydroisoindol-2-ium-2-yl)ethyl]azanium,diiodide
Synonyms 4,5,6,7-Tetrachlor-2-methyl-2-(2-trimethylammonio-aethyl)-isoindolinium,Dijodid
trimethyl-[2-[4,5,6,7-tetrachloro-2-(tritritiomethyl)-1,3-dihydroisoindol-2-ium-2-yl]ethyl]azanium
4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide
chlorisondamine iodide
4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide
4,5,6,7-tetrachloro-2-methyl-2-(2-trimethylammonio-ethyl)-isoindolinium,diiodide
Description Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way[1].
Related Catalog
Target

nAChR[1]
In Vivo Chlorisondamine (0.2, 1.0, 5.0 μg; IV; single dosage) antagonizes the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks[1]. Animal Model: Rats (treated once with nicotine 0.4 mg/kg, s.c.)[1] Dosage: 0.2, 1.0, 5.0 μg Administration: IV; single dosage Result: Antagonized the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks.
References

[1]. Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83(2):527-535. doi:10.1111/j.1476-5381.1984.tb16517.x

[2]. Clarke PB, et al. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994 Feb;111(2):397-405.

[3]. Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83(2):527-535. doi:10.1111/j.1476-5381.1984.tb16517.x
Molecular Formula C14H20Cl4I2N2
Molecular Weight 611.94
Exact Mass 609.84700
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H400
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;N: Dangerous for the environment;
Risk Phrases 22-50
Safety Phrases 60-61
RIDADR UN 3077 9 / PGIII
HS Code 2933990090
Precursor  4

DownStream  0

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 96750-66-2 | Chemsrc address: https://www.chemsrc.com/en/baike/527742.html

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