The high specific activity tritium labeling of the ganglion??blocking nicotinic antagonist chlorisondamine

J Zezula, HYJ Wang, AS Woods…

Index: Zezula, Josef; Wang, Hay-Yan J.; Woods, Amina S.; Wise, Roy A.; Jacobson, Arthur E.; Rice, Kenner C. Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 5 p. 471 - 478

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Abstract

Abstract Chlorisondamine is a bisquaternary ganglion-blocking nicotinic antagonist that accumulates in dopaminergic, serotonergic, and noradrenergic cell bodies; the mechanism of uptake and time-course of retrograde transport are not known. Chlorisondamine could possibly be taken into monoaminergic neurons when blocked nicotinic receptors on those cells are internalized. In order to more easily study the mechanism of the capture and ...