DC Chemicals Limited
China
Product Name: Toloxatone (MD 69276)
Price: $400.0/100mg $700.0/250mg $1350.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Toloxatone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

29218-27-7

29218-27-7 structure

29218-27-7 structure

Name: Toloxatone
Chemical Name: 2-oxazolidinone, 5-(hydroxymethyl)-3-(3-methylphenyl)
CAS Number: 29218-27-7
Molecular Formula: C₁₁H₁₃NO₃
Molecular Weight: 207.23
Catalog: API Nervous system medication Antidepressant, manic
Create Date: 2018-07-21 12:55:09
Modify Date: 2024-01-08 19:12:06
Toloxatone (MD 69276) is a reversible monoamine oxidase A (MAOA) inhibitor[1]. Antidepressant[1].

Name	2-oxazolidinone, 5-(hydroxymethyl)-3-(3-methylphenyl)
Synonyms	5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone Humoryl Toloxatone 5-(Hydroxymethyl)-3-(m-tolyl)oxazolidin-2-one 5-hydroxymethyl-3-(3-methylphenyl)-2-oxazolidinone ToloxatonetoloxatonetoloxatoneToloxatone Perenum EINECS 249-522-2 MFCD00865391 Humoryl 5-(hydroxymethyl)-3-m-tolyl-2-oxazolidinone 5-Hydroxymethyl-3-(3-methylphenyl)oxazolidin-2-one

Description	Toloxatone (MD 69276) is a reversible monoamine oxidase A (MAOA) inhibitor[1]. Antidepressant[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAOA[1]
References	[1]. FMoureau, et al. A reversible monoamine oxidase inhibitor, toloxatone: spectrophotometric and molecular orbital studies of the interaction with flavin adenine dinucleotide (FAD). European Journal of Medicinal Chemistry. 1994, 29(4):269-277.

Density	1.245g/cm3
Boiling Point	358.9ºC at 760mmHg
Melting Point	76°
Molecular Formula	C₁₁H₁₃NO₃
Molecular Weight	207.23
Flash Point	170.9ºC
Exact Mass	207.09000
PSA	49.77000
LogP	1.37750
Vapour Pressure	8.9E-06mmHg at 25°C
Index of Refraction	1.57
Storage condition	2-8°C
Water Solubility	DMSO: >10mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ2867500

CHEMICAL NAME :: 2-Oxazolidinone, 5-hydroxymethyl-3-(m-tolyl)-

CAS REGISTRY NUMBER :: 29218-27-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H13-N-O3

MOLECULAR WEIGHT :: 207.25

WISWESSER LINE NOTATION :: T5NVOTJ AR C1& D1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1225 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,569,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,569,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,569,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	22
RIDADR	UN 3249
RTECS	RQ2867500
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%