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5957-80-2

5957-80-2 structure
5957-80-2 structure
  • Name: Carnosol
  • Chemical Name: carnosol
  • CAS Number: 5957-80-2
  • Molecular Formula: C20H26O4
  • Molecular Weight: 330.418
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-06-30 16:15:21
  • Modify Date: 2024-01-02 14:59:30
  • Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM.
Name carnosol
Synonyms (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
(7β)-11,12-Dihydroxy-7,20-epoxyabieta-8(14),9(11),12-trien-20-one
2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-
Carnosol
Description Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM.
Related Catalog
Target

IC50: 5.5 μM (RSK2)[1].

In Vitro It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1[1].
In Vivo Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged[1].
Animal Admin Mice[1] Mice are orally administrated Carnosol at 100 mg/kg or vehicle 5 times a week over a period of 31 days[1].
References

[1]. Wang L, et al. Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2. Oncotarget. 2018 Feb 6;9(76):34200-34212.
Density 1.3±0.1 g/cm3
Boiling Point 524.8±50.0 °C at 760 mmHg
Molecular Formula C20H26O4
Molecular Weight 330.418
Flash Point 187.0±23.6 °C
Exact Mass 330.183105
PSA 66.76000
LogP 3.71
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.607
Storage condition −20°C
Hazard Codes F+
Safety Phrases 24/25
RIDADR NONH for all modes of transport
Precursor  1

DownStream  1


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title: CAS No. 5957-80-2 | Chemsrc address: https://www.chemsrc.com/en/baike/390363.html

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