328-38-1

328-38-1 structure

Name: H-D-Leu-OH
Chemical Name: D-leucine
CAS Number: 328-38-1
Molecular Formula: C₆H₁₃NO₂
Molecular Weight: 131.173
Catalog: Biochemical Amino acids and their derivatives --amino acid
Create Date: 2018-08-09 20:27:33
Modify Date: 2024-01-02 10:10:08
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

Name	D-leucine
Synonyms	leucine D-Leucine MFCD00063088 (R)-2-Amino-4-methylpentanoic acid (2R)-2-amino-4-methylpentanoic acid ent-1 H-Leu-OH D-Homo-valine D-2-Amino-4-methylvaleric acid H-D-Leu-OH (R)-2-Amino-4-methyl-pentanoic acid Leucine, D- EINECS 206-327-7 D-2-Amino-4-methylpentanoicacid

Description	D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
Related Catalog	Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1].
References	[1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OH2840000
HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%