943962-47-8
943962-47-8 structure
- Name: BMS 303141
- Chemical Name: Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)
- CAS Number: 943962-47-8
- Molecular Formula: C19H15Cl2NO4S
- Molecular Weight: 424.298
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ATP Citrate Lyase
- Create Date: 2017-02-07 13:19:12
- Modify Date: 2024-01-02 22:23:11
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BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
| Name | Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl) |
|---|---|
| Synonyms |
Benzenesulfonamide, 2,4-dichloro-5-hydroxy-N-(4-methoxy[1,1'-biphenyl]-2-yl)-
3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide BMS 303141 2,4-Dichloro-5-hydroxy-N-(4-methoxy-2-biphenylyl)benzenesulfonamide 3,5-dichloro-2-hydroxy-N-(4-methoxybiphenyl-3-yl)benzenesulfonamide Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)- 3,5-Dichloro-2-hydroxy-N-(4-methoxy-3-biphenylyl)benzenesulfonamide BMS-303141 |
| Description | BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.13 uM (ACL)[1] |
| In Vitro | In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity[1]. |
| In Vivo | Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h[1]. |
| Animal Admin | Mice: Effect of BMS-303141 in high-fat fed mice is studied. There are a total of four groups in the study; mice on normal diet and high-fat diet controls, and two treated groups that are supplemented with BMS-303141 in their high-fat diet to an equivalent daily dose of 10 or 100 mg/kg. The study is continued for a total of 34 days. Food consumption and body weight gain are tracked along with weekly assessment of lipid and glucose plasma chemistries[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 594.9±60.0 °C at 760 mmHg |
| Molecular Formula | C19H15Cl2NO4S |
| Molecular Weight | 424.298 |
| Flash Point | 313.6±32.9 °C |
| Exact Mass | 423.009888 |
| PSA | 84.01000 |
| LogP | 5.39 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.653 |
| Storage condition | 2-8℃ |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |