BMS 303141
Modify Date: 2024-01-02 22:23:11
BMS 303141 structure
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Common Name | BMS 303141 | ||
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| CAS Number | 943962-47-8 | Molecular Weight | 424.298 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 594.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C19H15Cl2NO4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 313.6±32.9 °C | |
Use of BMS 303141BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM. |
| Name | Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl) |
|---|---|
| Synonym | More Synonyms |
| Description | BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM. |
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| Related Catalog | |
| Target |
IC50: 0.13 uM (ACL)[1] |
| In Vitro | In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity[1]. |
| In Vivo | Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h[1]. |
| Animal Admin | Mice: Effect of BMS-303141 in high-fat fed mice is studied. There are a total of four groups in the study; mice on normal diet and high-fat diet controls, and two treated groups that are supplemented with BMS-303141 in their high-fat diet to an equivalent daily dose of 10 or 100 mg/kg. The study is continued for a total of 34 days. Food consumption and body weight gain are tracked along with weekly assessment of lipid and glucose plasma chemistries[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 594.9±60.0 °C at 760 mmHg |
| Molecular Formula | C19H15Cl2NO4S |
| Molecular Weight | 424.298 |
| Flash Point | 313.6±32.9 °C |
| Exact Mass | 423.009888 |
| PSA | 84.01000 |
| LogP | 5.39 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.653 |
| Storage condition | 2-8℃ |
| Hazard Statements | H413 |
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| RIDADR | NONH for all modes of transport |
| Benzenesulfonamide, 2,4-dichloro-5-hydroxy-N-(4-methoxy[1,1'-biphenyl]-2-yl)- |
| 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide |
| BMS 303141 |
| 2,4-Dichloro-5-hydroxy-N-(4-methoxy-2-biphenylyl)benzenesulfonamide |
| 3,5-dichloro-2-hydroxy-N-(4-methoxybiphenyl-3-yl)benzenesulfonamide |
| Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)- |
| 3,5-Dichloro-2-hydroxy-N-(4-methoxy-3-biphenylyl)benzenesulfonamide |
| BMS-303141 |