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482-45-1

482-45-1 structure
482-45-1 structure
  • Name: Isoimperatorin
  • Chemical Name: isoimperatorin
  • CAS Number: 482-45-1
  • Molecular Formula: C16H14O4
  • Molecular Weight: 270.280
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-09-10 17:25:29
  • Modify Date: 2025-08-20 18:54:50
  • Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.
Name isoimperatorin
Synonyms 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-buten-1-yl)oxy]-
IisoiMperatorin
buten-1-yl)oxy]
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-butenyl)oxy]-
Iso Imperatorin
Isoimperatoin
MFCD00272155
4-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
7H-Furo[3,2-g][1]benzopyran-7-one, 4-((3-methyl-2-butenyl)oxy)-
Isoimperatorin
4-PRENYLOXYPSORALEN
Isomperatorin
Auraptin
isoimperatonin
4-[(3-Methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((3-methyl-2-butenyl)oxy)-
Cnidin
Description Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.
Related Catalog
Target

IC50: 74.6 μM (AChE)[1]

In Vitro During a screening program for new agrochemicals from Chinese medicinal herbs, the ethanol extract of Notopterygium incisum rhizomes is found to possess strong nematicidal activity against the two species of nematodes, Bursaphelenchus xylophilus and Meloidogyne incognita. Based on bioactivity-guided fractionation, the four constituents are isolated from the ethanol extract and identified as Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin. Isoimperatorin also has LC50 values of 21.83 μg/mL against B. xylophilus. When using 15 min UV light treatment, falcarindiol, falcarinol, and isoimperatorin demonstrated almost five times more toxic to the southern root-knot nematodes than in dark treatment while columbianetin showed only two times more toxic. isoimperatorin has been demonstrated to possess insecticidal activity against several insects, such as the cabbage aphid (Brevicoryne brassicae)[2]. Isoimperatorin is identified in the active fraction of Angelica dahurica (AD) extract[3]. Isoimperatorin is usually used as the internal standard (IS)[4].
References

[1]. Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9.

[2]. Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276.

[3]. Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e0158796.

[4]. Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.
Density 1.2±0.1 g/cm3
Boiling Point 448.3±45.0 °C at 760 mmHg
Melting Point 109ºC
Molecular Formula C16H14O4
Molecular Weight 270.280
Flash Point 224.9±28.7 °C
Exact Mass 270.089203
PSA 52.58000
LogP 3.88
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.606
Storage condition -20°C Freezer
RIDADR NONH for all modes of transport
RTECS LV1513000
486-60-2 structure

486-60-2

870-63-3 structure

870-63-3

~75%

482-45-1 structure

482-45-1

Literature: Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 - 1610
484-20-8 structure

484-20-8

~%

482-45-1 structure

482-45-1

Literature: Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 - 1610
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