Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Desmethoxyyangonin
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Desmethoxyyangonin
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: demethoxyyangonin
Price: $280.0/20mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,6-Dehydrokawain
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Purity: 98.0%
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15345-89-8

15345-89-8 structure

15345-89-8 structure

Name: Desmethoxyyangonin
Chemical Name: Desmethoxy Yangonin
CAS Number: 15345-89-8
Molecular Formula: C₁₄H₁₂O₃
Molecular Weight: 228.243
Catalog: Natural product Phenols
Create Date: 2018-03-07 08:00:00
Modify Date: 2025-08-27 08:39:56
Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

Name	Desmethoxy Yangonin
Synonyms	DIHYDROKAVAIN 2H-Pyran-2-one, 4-methoxy-6-(2-phenylethenyl)- 2H-Pyran-2-one, 4-methoxy-6-[(E)-2-phenylethenyl]- 4-Methoxy-6-[(E)-2-phenylvinyl]-2H-pyran-2-one 4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one Desmethoxyyangonin (E)-4-Methoxy-6-(2-phenylethenyl)-2H-pyran-2-one,5,6-Dehydrokavain,Demethoxyyangonin

Description	Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Others Natural Products >> Others
References	[1]. Uebelhack R, et al. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998 Sep;31(5):187-92. [2]. Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20. [3]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24.

Density	1.2±0.1 g/cm3
Boiling Point	440.0±45.0 °C at 760 mmHg
Melting Point	138-140ºC
Molecular Formula	C₁₄H₁₂O₃
Molecular Weight	228.243
Flash Point	188.0±23.3 °C
Exact Mass	228.078644
PSA	39.44000
LogP	1.80
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.588
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ1240000

CHEMICAL NAME :: 2H-Pyran-2-one, 4-methoxy-6-styryl-, (E)-

CAS REGISTRY NUMBER :: 15345-89-8

LAST UPDATED :: 199206

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

WISWESSER LINE NOTATION :: T6OVJ DO1 F1U1R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

RIDADR	NONH for all modes of transport

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