15345-89-8

• 常用中文名：去甲氧基醉椒素
• 常用英文名：Desmethoxyyangonin
• CAS号：15345-89-8
• 分子式：C₁₄H₁₂O₃
• 分子量：228.243
• 相关类别： 天然产物 酚类
• 发布时间：2018-03-07 08:00:00
• 更新时间：2024-01-03 09:16:11
• 去甲氧基醉椒素(Desmethoxyyangonin)是MAO-B可逆性抑制剂。

名称

• 中文名: 去甲氧基醉椒素
• 英文名: Desmethoxy Yangonin
• 中文别名: (E)-4-甲氧基-6-苯乙烯基-2H-吡喃-2-酮; 卡文内酯
• 英文别名: DIHYDROKAVAIN; 2H-Pyran-2-one, 4-methoxy-6-(2-phenylethenyl)-; 2H-Pyran-2-one, 4-methoxy-6-[(E)-2-phenylethenyl]-; 4-Methoxy-6-[(E)-2-phenylvinyl]-2H-pyran-2-one; 4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one; Desmethoxyyangonin; (E)-4-Methoxy-6-(2-phenylethenyl)-2H-pyran-2-one,5,6-Dehydrokavain,Demethoxyyangonin

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 440.0±45.0 °C at 760 mmHg
• 熔点: 138-140ºC
• 分子式: C₁₄H₁₂O₃
• 分子量: 228.243
• 闪点: 188.0±23.3 °C
• 精确质量: 228.078644
• PSA: 39.44000
• LogP: 1.80
• 外观性状: 白色至淡的黄色粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.588
• 储存条件: 2-8°C

生物活性

• 描述: 去甲氧基醉椒素(Desmethoxyyangonin)是MAO-B可逆性抑制剂。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 其他
  天然产物 >> 其他
• 参考文献:

  [1]. Uebelhack R, et al. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998 Sep;31(5):187-92.

  [2]. Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20.

  [3]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ1240000 CHEMICAL NAME : 2H-Pyran-2-one, 4-methoxy-6-styryl-, (E)- CAS REGISTRY NUMBER : 15345-89-8 LAST UPDATED : 199206 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C14-H12-O3 MOLECULAR WEIGHT : 228.26 WISWESSER LINE NOTATION : T6OVJ DO1 F1U1R DO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 55 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

安全

• 危险品运输编码: NONH for all modes of transport