Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3-n-Butylphthalide
Price: Check
Purity: 97.1%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: 3-n-Butylphthalide
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

DC Chemicals Limited
China
Product Name: 3-n-Butylphathlide
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-butyl phthalide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

6066-49-5

6066-49-5 structure

Name: 3-n-Butylphthalide
Chemical Name: 3-Butylisobenzofuran-1(3H)-one
CAS Number: 6066-49-5
Molecular Formula: C₁₂H₁₄O₂
Molecular Weight: 190.238
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-07-04 00:27:41
Modify Date: 2024-01-02 00:03:09
Butylphthalide(3-n-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of stroke.IC50 value:Target:3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits [2]. Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved spatial learning and memory ability. Moreover, the loss of choline acetyltransferase (ChAT)-positive neurons in the medial septal nucleus and the vertical limb of the diagonal band in SAMP8 mice was slowed down, as was the decline in the protein and mRNA expression of ChAT in the hippocampus, cerebral cortex, and forebrain [4].

Name	3-Butylisobenzofuran-1(3H)-one
Synonyms	3-Butyl-phthalide 1(3H)-Isobenzofuranone, 3-butyl- 3-Butyl-2-benzofuran-1(3H)-one UNII:822Q956KGM Butylphthalide 3-n-butylphthalide 3-Butylphthalide EINECS 228-000-8

Description	Butylphthalide(3-n-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of stroke.IC50 value:Target:3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits [2]. Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved spatial learning and memory ability. Moreover, the loss of choline acetyltransferase (ChAT)-positive neurons in the medial septal nucleus and the vertical limb of the diagonal band in SAMP8 mice was slowed down, as was the decline in the protein and mRNA expression of ChAT in the hippocampus, cerebral cortex, and forebrain [4].
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Neurological Disease
References	[1]. Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl). 2013;126(18):3405-10. [2]. Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26. [3]. Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12(31):5995-6004. [4]. Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36(3):224-33.

Density	1.1±0.1 g/cm3
Boiling Point	312.8±31.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₄O₂
Molecular Weight	190.238
Flash Point	128.3±22.2 °C
Exact Mass	190.099380
PSA	26.30000
LogP	3.08
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.525

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3692000

CHEMICAL NAME :: Phthalide, 3-butyl-

CAS REGISTRY NUMBER :: 6066-49-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H14-O2

MOLECULAR WEIGHT :: 190.26

WISWESSER LINE NOTATION :: T56 BVO DHJ D4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,251,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,251,1979

HS Code	2932209090

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3413-15-8	6066-49-5
77989-13-0	1002753-71-0
404868-52-6	112162-79-5
94820-41-4	67905-67-3
104361-52-6	62717-46-8
1956371-15-5	1805044-93-2
1806828-53-4	1804451-21-5
1805242-94-7	1804491-58-4
1806794-18-2	1804843-09-1
1261846-73-4	1806832-26-7