6066-49-5

• 常用中文名：丁苯酞
• 常用英文名：3-n-Butylphthalide
• CAS号：6066-49-5
• 分子式：C₁₂H₁₄O₂
• 分子量：190.238
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-07-04 00:27:41
• 更新时间：2026-06-29 19:39:06
• Butylphthalide(3-n-Butylphthalide)是抗脑缺血药物,最初从芹菜种中分离出,对中风动物模型显示有效。

名称

• 中文名: 3-丁基-1(3H)-异苯并呋喃酮
• 英文名: 3-Butylisobenzofuran-1(3H)-one
• 中文别名: 丁基酞内酯对照品; 正丁基苯酞丁苯酞; 芹菜甲素 丁苯酞); 3-N-BUTYLPHATHLIDE 正丁基苯酞; 3-丁基-1(3H)-异苯并呋喃酮(丁苯酞); 丁基酞内酯; 正丁基苯酞(对照品); 丁苯酞杂质38; 3-丁基苯酞; 丁基苯酞,10 MM DMSO 溶液; 氘7-丁基酞酸酯(氘7-NBP); 3-丁基酞; 丁基酞内酯(标准品); 丁苯肽; 芹菜甲素; 正丁基苯酞3-Butylphthalide; 正丁基苯酞; 丁苯酞杂质55; 3-丁基异苯并呋喃-1(3H)-酮; 丁苯酞标准品035; 丁基苯酞; 丁基苯酞杂质; 正丁基苯酞(丁基酞内酯; 正丁基苯酞(正丁基苯肽; 3-N-Butylphthalide丁苯酞; 正丁基苯酞;丁基酞内酯（标准品）; 3-丁苯酞; 丁苯酞杂质49; 丁基苯酞杂质55; 丁苯酞-D7同位素; 丁基苯酞; 苯酞标准品 内标; 正丁基苯酞 丁苯; 丁基酞内酯(液态); 正丁基苯肽; 3-丁基苯酞(正丁基苯酞)
• 英文别名: 1(3H)-Isobenzofuranone, 3-butyl; butylphthalide; Butylphthalide, 10 mM in DMSO; 3-butylisobenzofuran-1-ol; 3-butyl-phthalid; 3-butyl-1(3H)-Isobenzofuranone; Butylphathlide; DL-3-n-Butylphthalide; High quality 3-N-Butylphthalide; BUTYLPHTHALIDE, 3-n-(P); 3-n-Butylphathlide; 3-Butylisobenzofuran-1(3H); 3-N-BUTYLPHTHALIDE; Butyphthalide impurity 49; 3-N-BUTYLPHTALIDE; CL234; Butylphthalide Impurity 55; 3-Butylphthalide; UNII:822Q956KGM; Butylphthalide; n-Butylphthalide; Butylphthalide (Natural); EINECS 228-000-8; 3-N-BUTYLPHTHALIDE //BP; 3-Butyl-phthalide; 3-butyl-3H-2-benzofuran-1-one; 3-butyl-1(3h)-isobenzofuranon; D7-Butylphthalide(D7-NBP); n-Butylphthalide-035; 3-Butyl-2-benzofuran-1(3H)-one; 3-N-Butylphehalide; 3-N-BUTYLPHTHALIDE CAS 6066 49 5; Butylphthalein; 3-n-butylphthalide

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 312.8±31.0 °C at 760 mmHg
• 分子式: C₁₂H₁₄O₂
• 分子量: 190.238
• 闪点: 128.3±22.2 °C
• 精确质量: 190.099380
• PSA: 26.30000
• LogP: 3.08
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.525
• 储存条件: 库房通风低温干燥

生物活性

• 描述: Butylphthalide(3-n-Butylphthalide)是抗脑缺血药物,最初从芹菜种中分离出,对中风动物模型显示有效。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl). 2013;126(18):3405-10.

  [2]. Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26.

  [3]. Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12(31):5995-6004.

  [4]. Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36(3):224-33.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TI3692000 CHEMICAL NAME : Phthalide, 3-butyl- CAS REGISTRY NUMBER : 6066-49-5 LAST UPDATED : 199701 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C12-H14-O2 MOLECULAR WEIGHT : 190.26 WISWESSER LINE NOTATION : T56 BVO DHJ D4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,251,1979 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,251,1979

安全

• 海关编码: 2932209090

海关

海关编码	2932209090
中文概述	2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%