Top Suppliers:I want be here
Related CAS#:
54556-98-8 1329509-71-8
1406-14-0 6138-79-0
127228-87-9 143851-98-3
929-73-7 65546-09-0
1135280-78-2 56-99-5
80232-88-8 43073-13-8
754970-69-9 243636-52-4
313468-94-9 25825-32-5
128186-39-0 151697-22-2
227471-64-9 2760-11-4

54556-98-8

54556-98-8 structure
54556-98-8 structure
  • Name: Propiverine hydrochloride
  • Chemical Name: Propiverine Hydrochloride
  • CAS Number: 54556-98-8
  • Molecular Formula: C23H30ClNO3
  • Molecular Weight: 403.942
  • Catalog: API Urinary system medication Diabetes insipidus medication
  • Create Date: 2018-04-15 08:00:00
  • Modify Date: 2025-08-22 22:42:54
  • Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2].
Name Propiverine Hydrochloride
Synonyms Mictonetten
Mictonorm
Propiverine hydrochloride
Propiverine Hydrochlorride
1-Methyl-4-piperidinyl diphenyl(propoxy)acetate hydrochloride (1:1)
Propiverine HCl
UNII-DC4GZD10H3
Benzeneacetic acid, α-phenyl-α-propoxy-, 1-methyl-4-piperidinyl ester, hydrochloride (1:1)
1-Methylpiperidin-4-yl diphenyl(propoxy)acetate hydrochloride (1:1)
Description Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2].
Related Catalog
In Vitro Propiverine (10-3000 nM) inhibits the specific binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively[2].
In Vivo Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats[1]. Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo[1]. Animal Model: Female adult Sprague-Dawley rats (250-270 g)[1] Dosage: 5 mg dissolved in distilled water (0.5 mL) Administration: P.o. once daily for 2 weeks Result: Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly. Increased plasma epinephrine and norepinephrine levels. No significant changes were observed in body weight.
References

[1]. Kitta T, et, al. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J. 2013 Apr; 24(4): 683-8.

[2]. Ito Y, et, al. Muscarinic Receptor Binding and Plasma Drug Concentration after the Oral Administration of Propiverine in Mice. Low Urin Tract Symptoms. 2010 Apr; 2(1):43-9.
Boiling Point 494.7ºC at 760 mmHg
Melting Point 213-216ºC
Molecular Formula C23H30ClNO3
Molecular Weight 403.942
Flash Point 253ºC
Exact Mass 403.191437
PSA 38.77000
LogP 4.73410
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH3297000
CHEMICAL NAME :
Acetic acid, diphenylpropoxy-, 1-methyl-4-piperidyl ester, hydrochloride
CAS REGISTRY NUMBER :
54556-98-8
LAST UPDATED :
199403
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C23-H29-N-O3.Cl-H
MOLECULAR WEIGHT :
403.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18200 mg/kg/1Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Liver - changes in liver weight Endocrine - changes in pituitary weight
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 15,107,1990 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 37/38-41
Safety Phrases 26-39
RIDADR NONH for all modes of transport
RTECS AH3297000
HS Code 2933399090
106-52-5 structure

106-52-5

94686-44-9 structure

94686-44-9

~%

54556-98-8 structure

54556-98-8

Literature: WO2011/114195 A1, ; Page/Page column 6-7 ;
Precursor  1

DownStream  1

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:54556-98-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 54556-98-8 | Chemsrc address: https://www.chemsrc.com/en/baike/248871.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved