Top Suppliers:I want be here
Related CAS#:
34433-31-3 22615-60-7
59779-47-4 762-86-7
15230-70-3 13470-12-7
28853-36-3 4708-07-0
1983-27-3 13874-77-6
863003-66-1 847400-53-7
852366-85-9 852366-86-0
852366-87-1 852373-35-4
863457-84-5 863458-01-9
863458-69-9 863458-85-9

34433-31-3

34433-31-3 structure
34433-31-3 structure
  • Name: Asoxime dichloride
  • Chemical Name: asoxime chloride
  • CAS Number: 34433-31-3
  • Molecular Formula: C14H16Cl2N4O3
  • Molecular Weight: 359.20800
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
  • Create Date: 2017-12-02 04:38:06
  • Modify Date: 2025-08-27 15:33:48
  • Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].
Name asoxime chloride
Synonyms Pralidoxime
hi-6dichloride
hj6
hi6
HI 6 Chloride
Description Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].
Related Catalog
Target

IC50: acetylcholine receptors (AChRs)[1]

In Vivo Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant[1]. Animal Model: Balb/c mice[1] Dosage: 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg Administration: Intramuscular injection into the rear limb Result: Improved vaccination efficacy at the level of immunity regulation by the nervous system.
References

[1]. Pohanka M, et al. HI-6 modulates immunization efficacy in a BALB/c mouse model.Environ Toxicol Pharmacol. 2013 Nov;36(3):801-6.
Melting Point 145-147ºC
Molecular Formula C14H16Cl2N4O3
Molecular Weight 359.20800
Exact Mass 358.06000
PSA 92.67000
Storage condition 20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU2990000
CHEMICAL NAME :
Pyridinium, 4'-carbamoyl-2-formyl-1,1'-(oxydimethylene)di-, dichloride, 2-oxime
CAS REGISTRY NUMBER :
34433-31-3
LAST UPDATED :
199703
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C14-H16-N4-O3.2Cl
MOLECULAR WEIGHT :
359.24
WISWESSER LINE NOTATION :
T6KJ B1UNQ A1O1- AT6KJ DVZ &G 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
819 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
295 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
168 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
451 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
476 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg/14D-I
TOXIC EFFECTS :
Blood - changes in platelet count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1960 mg/kg/14D-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
750 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 27,152,1996
RIDADR NONH for all modes of transport
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:34433-31-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 34433-31-3 | Chemsrc address: https://www.chemsrc.com/en/baike/247287.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved