331963-27-0
331963-27-0 structure
- Name: GSK3-IN-3
- Chemical Name: GSK3-IN-3
- CAS Number: 331963-27-0
- Molecular Formula: C24H35N3O4
- Molecular Weight: 429.55
- Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
- Create Date: 2023-06-17 21:16:12
- Modify Date: 2025-08-26 19:24:28
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GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA[1][2][3].
| Name | GSK3-IN-3 |
|---|
| Description | GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA[1][2][3]. |
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| Related Catalog | |
| Target |
IC50: 3.01 μM (GSK-3)[3] |
| In Vitro | GSK3-IN-3 (VP07)（25 μM；24 小时）在表达 Parkin 的 U2OS-iMLS 细胞中诱导线粒体自噬，但效力有限[1]。 GSK3-IN-3（1.56-25 μM；24 小时）导致 U2OS-iMLS-Parkin 细胞发生线粒体分裂和线粒体形态变化[1]。 GSK3-IN-3 (VP0.7)（5 μM，10 μM；）在 SH-SY5Y 细胞的帕金森病体外细胞模型中显示出针对 6-OHDA 的神经保护作用[2]。< br/> Immunofluorescence[1] Cell Line: Parkin-expressing U2OS-iMLS cells Concentration: 1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM, and 25 μM; Incubation Time: 24 hours Result: Induced a mitochondrial morphology change from a filament-shaped network to a more round-shaped network. Cell Viability Assay[2] Cell Line: SH-SY5Y cells Concentration: 0.5 μM, 1 μM, 3 μM, 5 μM, and 10 μM Incubation Time: 16 hours; with 35 μM 6-OHDA Result: Inhibited cell growth with an IC50 value of 2.57 μM. |
| References |
| Molecular Formula | C24H35N3O4 |
|---|---|
| Molecular Weight | 429.55 |