551909-15-0

551909-15-0 structure

Name: RTICBM-189
Chemical Name: RTICBM-189
CAS Number: 551909-15-0
Molecular Formula: C₁₅H₁₄Cl₂N₂O
Molecular Weight: 309.19
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2022-02-21 17:58:44
Modify Date: 2025-08-26 12:14:01
RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1].

Name	RTICBM-189

Description	RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1:7.54 (pIC50) hCB1:5.29 (pIC50) mCB1:6.25 (pIC50)
In Vivo	RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1]. RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1]. Animal Model: Adult male Sprague-Dawley rats weighing 280-300 g[1] Dosage: 10 mg/kg Administration: IP Result: Significantly attenuated drug-induced reinstatement of the cocaine-seeking behavior. Animal Model: Male Sprague-Dawley rats weighing 258-277 g[1] Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: IP Result: Plasma: Cmax (288.4 ng/mL), tmax (0.4 hours), CL_F (240.6 mL/min/kg), AUCinf (715.2 ng/mL × h), half-life t1/2 (9.9 hours).Brain: Cmax (594.6 ng/mL), tmax (0.4 hours), CL_F (120.7 mL/min/kg), AUCinf (1438.2 ng/mL × h).
References	[1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432.

Molecular Formula	C₁₅H₁₄Cl₂N₂O
Molecular Weight	309.19

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

551909-15-0	2130881-32-0
2250355-35-0	1270138-40-3
55381-18-5	14265-84-0
178535-83-6	15765-78-3
15055-30-8	152584-38-8
750538-32-0	131988-14-2
69584-89-0	131988-25-5
80650-73-3	131988-31-3
205496-94-2	131988-16-4
141775-40-8	136672-34-9