711085-63-1

711085-63-1 structure

Name: PNU 282987
Chemical Name: Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
CAS Number: 711085-63-1
Molecular Formula: C₁₄H₁₇ClN₂O
Molecular Weight: 264.75
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2022-01-09 15:29:51
Modify Date: 2024-01-10 18:06:28
PNU-282987 (free base) (Compound C7) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM[1].

Name	Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
Synonyms	MFCD08703110

Description	PNU-282987 (free base) (Compound C7) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT3 Receptor
References	[1]. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

Molecular Formula	C₁₄H₁₇ClN₂O
Molecular Weight	264.75

Hazard Codes	Xi