1990492-86-8

1990492-86-8 structure

Name: MARK-IN-4
Chemical Name: MARK-IN-4
CAS Number: 1990492-86-8
Molecular Formula: C₂₁H₂₃N₇OS
Molecular Weight: 421.52
Catalog: Signaling Pathways Epigenetics AMPK
Create Date: 2022-01-04 10:10:27
Modify Date: 2024-01-09 21:52:44
MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].

Name	MARK-IN-4

Description	MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Neurological Disease
References	[1]. Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016;26(17):4362-4366.

Molecular Formula	C₂₁H₂₃N₇OS
Molecular Weight	421.52

Hazard Codes	Xi