36681-58-0

36681-58-0 structure

Name: Kynuramine dihydrochloride
Chemical Name: 3-Amino-1-(2-aminophenyl)-1-propanone dihydrochloride
CAS Number: 36681-58-0
Molecular Formula: C₉H₁₄Cl₂N₂O
Molecular Weight: 237.13
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2021-12-19 15:15:44
Modify Date: 2024-01-05 19:34:32
Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].

Name	3-Amino-1-(2-aminophenyl)-1-propanone dihydrochloride
Synonyms	1-Propanone, 3-amino-1-(2-aminophenyl)-, hydrochloride (1:2) 3-Amino-1-(2-aminophenyl)-1-propanone dihydrochloride MFCD28384025

Description	Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Metabolic Disease
In Vitro	Kynuramine inhibits both presynaptic and postsynaptic α-adrenoceptors in vitro[2]. Kynuramine has been shown to act as a partial agonist on serotonin receptors in dog cerebral arteries[2]. Kynuramine (20 μg/mL) frequently causes a small contraction of the ileum but failed to alter the twitch response to cholinergic stimulation[2].
In Vivo	Kynuramine may serve a physiological role in the modulation of female sexual behavior[3]. Kynuramine increases heart rate and blood pressure in pithed rats[4]. Animal Model: Female rats[3]. Dosage: 0.064-8 μg. Administration: Intraventricular administration. Result: Produced facilitation of lordosis behavior.
References	[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.