1026136-84-4
1026136-84-4 structure
- Name: Nelonicline citrate
- Chemical Name: Nelonicline citrate
- CAS Number: 1026136-84-4
- Molecular Formula: C23H27N3O8S
- Molecular Weight: 505.54
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2021-10-13 22:19:44
- Modify Date: 2025-08-27 08:26:00
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Nelonicline (ABT-126) citrate is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline citrate is used for the research of shizophrenia and Alzheimer's disease[1][2][3].
| Name | Nelonicline citrate |
|---|
| Description | Nelonicline (ABT-126) citrate is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline citrate is used for the research of shizophrenia and Alzheimer's disease[1][2][3]. |
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| Related Catalog | |
| In Vitro | Nelonicline citrate is an agonist that binds with high affinity to α7 nAChRs in human brain (Ki= 12.3 nM) and activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50=2 μM; intrinsic activity of 74% relative to acetylcholine). Nelonicline citrate does bind to α3β4* nAChRs in human IMR-32 neuroblastoma cells (Ki=60 nM), but has only 12% efficacy at 100,000 nM in a calcium flux assay in these cell. Like some other α7 nAChR agonists, Nelonicline citrate is also a 5-HT3 receptor antagonist, but it has >10-fold lower affinity for this receptor than for α7 nAChRs (Ki of 140 nM)[1]. |
| References |
| Molecular Formula | C23H27N3O8S |
|---|---|
| Molecular Weight | 505.54 |