170964-68-8

170964-68-8 structure

Name: Tetrindole
Chemical Name: Tetrindole mesylate
CAS Number: 170964-68-8
Molecular Formula: C₂₁H₃₀N₂O₃S
Molecular Weight: 390.54
Create Date: 2021-01-11 07:17:01
Modify Date: 2025-08-21 11:24:31
Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2].

Name	Tetrindole mesylate
Synonyms	MFCD00367633 8-Cyclohexyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole methanesulfonate (1:1) Tetrindole mesylate 1H-Pyrazino[3,2,1-jk]carbazole, 8-cyclohexyl-2,3,3a,4,5,6-hexahydro-, methanesulfonate (1:1)

Description	Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO-A
In Vitro	Tetrindole mesylate 对 6 种人乳腺肿瘤细胞系 (MCF-7、HCC1954、T47D、MDA-MB-157、ZR75-1、BT474) 的 IC50 值为 0.51-1.37 μM[2]。
In Vivo	Tetrindole mesylate (25 mg/kg; 口服灌胃; 单剂量) 在体重 180-200 的雄性白化大鼠中，0.5-1 小时内抑制脑和肝脏线粒体 MAO A 80%，并且 24 小时后酶活性开始明显恢复 g[1]。
References	[1]. A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47(2):303-8. [2]. William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59.