Tetrindole
Modify Date: 2025-08-21 11:24:31
Tetrindole structure
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Common Name | Tetrindole | ||
|---|---|---|---|---|
| CAS Number | 170964-68-8 | Molecular Weight | 390.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H30N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TetrindoleTetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2]. |
| Name | Tetrindole mesylate |
|---|---|
| Synonym | More Synonyms |
| Description | Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2]. |
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| Related Catalog | |
| Target |
MAO-A |
| In Vitro | Tetrindole mesylate 对 6 种人乳腺肿瘤细胞系 (MCF-7、HCC1954、T47D、MDA-MB-157、ZR75-1、BT474) 的 IC50 值为 0.51-1.37 μM[2]。 |
| In Vivo | Tetrindole mesylate (25 mg/kg; 口服灌胃; 单剂量) 在体重 180-200 的雄性白化大鼠中，0.5-1 小时内抑制脑和肝脏线粒体 MAO A 80%，并且 24 小时后酶活性开始明显恢复 g[1]。 |
| References |
| Molecular Formula | C21H30N2O3S |
|---|---|
| Molecular Weight | 390.54 |
| Exact Mass | 390.197723 |
| MFCD00367633 |
| 8-Cyclohexyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole methanesulfonate (1:1) |
| Tetrindole mesylate |
| 1H-Pyrazino[3,2,1-jk]carbazole, 8-cyclohexyl-2,3,3a,4,5,6-hexahydro-, methanesulfonate (1:1) |