1780372-25-9
1780372-25-9 structure
- Name: SB 243213 dihydrochloride
- Chemical Name: SB 243213 dihydrochloride
- CAS Number: 1780372-25-9
- Molecular Formula: C22H21Cl2F3N4O2
- Molecular Weight: 501.33
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-04-14 15:41:54
- Modify Date: 2025-08-20 15:24:55
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SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1].
| Name | SB 243213 dihydrochloride |
|---|
| Description | SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT2C Receptor:9.37 (pKi) |
| In Vitro | SB 243213 dihydrochloride shows little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows weak affinity (pKi<6.5) for the cloned human 5-HT1D and D3 receptors and moderate affinity (pKi=6.7) for the cloned human D2 receptor[1]. |
| In Vivo | SB 243213 dihydrochloride (0.1-10 mg/kg; p.o.; 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box[1]. SB 243213 dihydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction[1]. Animal Model: Male Sprague-Dawley experimentally naive rats (220-300 g)[1] Dosage: 0.1, 0.3, 1, 3, 10 mg/kg Administration: p.o.; 1 hour pre-test Result: Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. |
| References |
| Molecular Formula | C22H21Cl2F3N4O2 |
|---|---|
| Molecular Weight | 501.33 |