607373-46-6

607373-46-6 structure

Name: SB 772077B dihydrochloride
Chemical Name: [2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridi n-7-yl][(3S)-3-amino-1-pyrrolidinyl]methanone dihydrochloride
CAS Number: 607373-46-6
Molecular Formula: C₁₅H₂₀Cl₂N₈O₂
Molecular Weight: 415.28
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2016-06-12 13:20:23
Modify Date: 2024-04-03 18:24:26
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase( ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively[1].

Name	[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridi n-7-yl][(3S)-3-amino-1-pyrrolidinyl]methanone dihydrochloride
Synonyms	7,8-Dihydroxyflavone

Description	SB-772077B dihydrochloride is an aminofurazan-based Rho kinase( ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	ROCK1:5.6 nM (IC50) ROCK2:6 nM (IC50)
References	[1]. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.