1630936-95-6
1630936-95-6 structure
- Name: VU 0422288
- Chemical Name: ML396
- CAS Number: 1630936-95-6
- Molecular Formula: C17H11Cl2N3O2
- Molecular Weight: 360.194
- Create Date: 2020-01-11 17:59:35
- Modify Date: 2025-09-27 21:24:13
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VU0422288 is a potent, selective, CNS-penetrant pan-Group III mGlu positive allosteric modulator with IC50 of 110/146/130 nM for mGlu8/7/4, respectively, displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6).
| Name | ML396 |
|---|---|
| Synonyms |
ML396
N-(3-Chloro-4-((5-chloropyridin-2-yl)oxy)phenyl)picolinamide 2-Pyridinecarboxamide, N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]- N-{3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl}-2-pyridinecarboxamide MFCD28411626 VU0422288 |
| Description | VU0422288 is a potent, selective, CNS-penetrant pan-Group III mGlu positive allosteric modulator with IC50 of 110/146/130 nM for mGlu8/7/4, respectively, displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6). |
|---|---|
| References | References 1. Jalan-Sakrikar N, et al. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. View Related Products by Target mGluR |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 422.6±45.0 °C at 760 mmHg |
| Molecular Formula | C17H11Cl2N3O2 |
| Molecular Weight | 360.194 |
| Flash Point | 209.4±28.7 °C |
| Exact Mass | 359.022827 |
| LogP | 3.51 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.671 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |