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16423-68-0

16423-68-0 structure
16423-68-0 structure
  • Name: erythrosin B
  • Chemical Name: erythrosin B
  • CAS Number: 16423-68-0
  • Molecular Formula: C20H6I4Na2O5
  • Molecular Weight: 879.856
  • Catalog: Biochemical Biochemical reagent Biological dye
  • Create Date: 2018-08-19 11:25:14
  • Modify Date: 2024-01-05 03:58:07
  • Erythrosin B is an artificial dye widely used in the food and textile industries. Erythrosin B is also a novel photosensitizer which has been used to develop animal models.
Name erythrosin B
Synonyms 1427red
Erythrosin B,high purity,biological stain
Erythrosin
Tetraiodofluorescein sodium salt
Erythrosine Sodium (close form)
Disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
Benzoic acid, 2-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)-, sodium salt (1:2)
2',4',5',7'-Tetraiodofluorescein disodium salt
Erythrosin extra bluish
IODOEOSIN
FD & C Red 3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2)
EINECS 240-474-8
3',6'-Dihydroxy-2',4',5',7'-tetraiodospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one Disodium Salt
FDC red no. 3
Disodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
Sodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)
1671red
Food Red No. 3
c.i.773
Japan Red 3
EOSIN J
FD and C Red No. 3
Synerid
MFCD00144257
fdcred3
CRED3
ebs
Ceplac
Erythrosin B,certified
lb-rot1
Erythrosin B
Acid Red 51
Description Erythrosin B is an artificial dye widely used in the food and textile industries. Erythrosin B is also a novel photosensitizer which has been used to develop animal models.
Related Catalog
In Vitro Only the two highest concentrations of Erythrosin B tested (50.0 and 70.0 μg/mL) are significantly different (p<0.05) from the vehicle control group when the Tail Moment and Tail Intensity, which represent the extent of DNA damage, are analyzed. Results show increased micronuclei (MNi) frequencies at six of the seven Erythrosin B concentrations (0.2 to 70.0 μg/mL) when compare to vehicle control group[1].
Cell Assay The alkaline single-cell gel electrophoresis assay (comet assay) is performed. Briefly, 2×105 HepG2 cells are seeded in a 24-well plate for 24 h. The cells are then treated with Erythrosin B at 0.1, 0.2, 2.0, 10.0, 25.0, 50.0 or 70.0 μg/mL (final concentration) for 4 h; vehicle control (0.7% DMSO) and positive control (doxorubicin0.3 μg/mL) treatments are also performed. The HepG2 cell suspension is mixed with 37°C low-melting point agarose and transferred to normal-melting point agarose-coated slides. One hundred randomly chosen nucleoids are analyzed per treatment, and a total of three independent experiments are performed[1].
References

[1]. Chen W, et al. Establishing an experimental rat model of photodynamically-induced retinal vein occlusion using erythrosin B. Int J Ophthalmol. 2014 Apr 18;7(2):232-8.

[2]. Chequer FM, et al. Genotoxic and mutagenic effects of erythrosine B, a xanthene food dye, on HepG2 cells. Food Chem Toxicol. 2012 Oct;50(10):3447-51.
Density 0.98
Boiling Point 693.2ºC at 760 mmHg
Melting Point >300ºC (Decomposes)
Molecular Formula C20H6I4Na2O5
Molecular Weight 879.856
Flash Point 373ºC
Exact Mass 879.618896
PSA 81.65000
LogP 6.96060
Vapour Pressure 2.22E-16mmHg at 25°C
Storage condition Store at +5°C to +30°C.
Water Solubility 100g/l

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LM5950000
CHEMICAL NAME :
Fluorescein, 2',4',5',7'-tetraiodo-, disodium salt
CAS REGISTRY NUMBER :
16423-68-0
LAST UPDATED :
199710
DATA ITEMS CITED :
31
MOLECULAR FORMULA :
C20-H6-I4-O5.2Na
MOLECULAR WEIGHT :
879.84
WISWESSER LINE NOTATION :
T C666 BO EVJ DI FI IR BVQ& LI MQ NI &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1840 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1895 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1264 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - gerbil
DOSE/DURATION :
1930 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
90 gm/kg/90D-C
TOXIC EFFECTS :
Gastrointestinal - other changes Endocrine - changes in thyroid weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
147 gm/kg/14W-I
TOXIC EFFECTS :
Endocrine - changes in thyroid weight Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1798 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
482 gm/kg
SEX/DURATION :
multigeneration
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1100 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4011 No. of Facilities: 904 (estimated) No. of Industries: 5 No. of Occupations: 11 No. of Employees: 8221 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4011 No. of Facilities: 2991 (estimated) No. of Industries: 17 No. of Occupations: 39 No. of Employees: 67011 (estimated) No. of Female Employees: 25006 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H413
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LM5950000
HS Code 32129000

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