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105784-61-0

105784-61-0 structure
105784-61-0 structure
  • Name: temafloxacin hydrochloride
  • Chemical Name: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride
  • CAS Number: 105784-61-0
  • Molecular Formula: C21H19ClF3N3O3
  • Molecular Weight: 453.842
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2017-03-24 21:57:29
  • Modify Date: 2024-01-12 19:28:42
  • Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2].
Name 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride
Synonyms 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1)
3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, hydrochloride (1:1)
1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1)
UNII:OC5IGJ7J6I
6-Fluoro-1-(2,4-difluorophenyl)-1-4-dihydro-7-(3-methylpiperazin-1-yl)-4-oxo-3-quinoline-carboxylic acid hydrochloride
UNII-OC5IGJ7J6I
Omniflox (TN)
Temafloxacin HCl
(±)-1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid monohydrochloride
temafloxacin hydrochloride
Description Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2].
Related Catalog
In Vitro Temafloxacin hydrochloride (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1]. Cell Viability Assay[1] Cell Line: E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains) Concentration: 0-64 µg/mL Incubation Time: 18-24 h Result: Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 µg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: µg/mL).
In Vivo Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1]. Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1]. Animal Model: Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1]. Dosage: 6.25, 25, 100 mg/kg Administration: Orally; single. Result: Reduced the number of viable bacteria in the kidneys of mice. Animal Model: Female CF-1 mice (20-25 g)[1]. Dosage: 100 mg/kg Administration: Subcutaneously or orally; single. Result: 1.19Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1]. Cmax (µg/mL) AUC (µg/mL•h) T1/2 (h) % Urinary recovery SC (100 mg/kg) 25.2 86.6 3.4 25.3 PO (100 mg/kg) 13.5 57.4 1.3 9.1
References

[1]. Hardy DJ, et al. Comparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones. Antimicrob Agents Chemother. 1987 Nov;31(11):1768-74.

[2]. Pankey GA. Temafloxacin: an overview. Am J Med. 1991 Dec 30;91(6A):166S-172S.
Boiling Point 608.9ºC at 760 mmHg
Molecular Formula C21H19ClF3N3O3
Molecular Weight 453.842
Flash Point 322.1ºC
Exact Mass 453.106689
PSA 74.57000
LogP 4.10010
Vapour Pressure 1.11E-15mmHg at 25°C
Hazard Codes Xi

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