temafloxacin hydrochloride
Modify Date: 2025-08-21 11:45:27
temafloxacin hydrochloride structure
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Common Name | temafloxacin hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 105784-61-0 | Molecular Weight | 453.842 | |
| Density | N/A | Boiling Point | 608.9ºC at 760 mmHg | |
| Molecular Formula | C21H19ClF3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 322.1ºC | |
Use of temafloxacin hydrochlorideTemafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2]. |
| Name | 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Temafloxacin hydrochloride (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1]. Cell Viability Assay[1] Cell Line: E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains) Concentration: 0-64 µg/mL Incubation Time: 18-24 h Result: Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 µg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: µg/mL). |
| In Vivo | Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1]. Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1]. Animal Model: Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1]. Dosage: 6.25, 25, 100 mg/kg Administration: Orally; single. Result: Reduced the number of viable bacteria in the kidneys of mice. Animal Model: Female CF-1 mice (20-25 g)[1]. Dosage: 100 mg/kg Administration: Subcutaneously or orally; single. Result: 1.19Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1]. Cmax (µg/mL) AUC (µg/mL•h) T1/2 (h) % Urinary recovery SC (100 mg/kg) 25.2 86.6 3.4 25.3 PO (100 mg/kg) 13.5 57.4 1.3 9.1 |
| References |
[2]. Pankey GA. Temafloxacin: an overview. Am J Med. 1991 Dec 30;91(6A):166S-172S. |
| Boiling Point | 608.9ºC at 760 mmHg |
|---|---|
| Molecular Formula | C21H19ClF3N3O3 |
| Molecular Weight | 453.842 |
| Flash Point | 322.1ºC |
| Exact Mass | 453.106689 |
| PSA | 74.57000 |
| LogP | 4.10010 |
| Vapour Pressure | 1.11E-15mmHg at 25°C |
| Hazard Codes | Xi |
|---|
| 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1) |
| 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, hydrochloride (1:1) |
| 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1) |
| UNII:OC5IGJ7J6I |
| 6-Fluoro-1-(2,4-difluorophenyl)-1-4-dihydro-7-(3-methylpiperazin-1-yl)-4-oxo-3-quinoline-carboxylic acid hydrochloride |
| UNII-OC5IGJ7J6I |
| Omniflox (TN) |
| Temafloxacin HCl |
| (±)-1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid monohydrochloride |
| temafloxacin hydrochloride |
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