ATR-IN-15

Names

[ CAS No. ]:
2756665-52-6

[ Name ]:
ATR-IN-15

Biological Activity

[Description]:

ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK

[Target]

ATR:8 nM (IC50)

PI3K:5131 nM (IC50)

ATM:> 10000 nM (IC50)


[References]

[1]. Xin Li, et al. Imidazopyrimidine derivative, preparation method therefor and medical use thereof. WO2022002243A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H22N8O

[ Molecular Weight ]:
378.43

Related Compounds