Nicotinamide adenine dinucleotide phosphate

Names

[ CAS No. ]:
53-59-8

[ Name ]:
Nicotinamide adenine dinucleotide phosphate

[Synonym ]:
NADPH
NADP-ox
NADP+
COENZYME II
b-Nicotinamide Adenine Dinucleotide Phosphate
cozymaseii
β-Nicotinamide Adenine Dinucleotide Phosphate
TPNH
b-NADP
β-Triphosphopyridine Nucleotide
TPN
Triphosphopyridinnucleotid
3-Carbamoyl-1-b-D-ribofuranosylpyridinium Hydroxide 5'®5'-Ester with Adenosine 2'-(Dihydrogen Phosphate) 5'-(Trihydrogen Pyrophosphate) Inner Salt
Co II
Adenosine 5'-(Trihydrogen Diphosphate) 2'-(Dihydrogen Phosphate) P'®5'-Ester with 3-(Aminocarbonyl)-1-b-D-ribofuranosylpyridinium Hydroxide Inner Salt
Beta-NADP,Monopotassium Salt
MFCD10567218
NADP
b-TPN
β-Nicotinamide adenine dinucleotide phosphate (NADP)
Triphosphopyridine Nucleotid
Triphosphopyridine nucleotide

Biological Activity

[Description]:

NADP is nicotinamide adenine dinucleotide phosphate, acting as a key cofactor for electron transfer in the metabolism of all organisms, being alternately oxidized (NADP+) and reduced (NADPH).

[Related Catalog]:

Natural Products >> Others

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Zhao FL, et al. A genetically encoded biosensor for in vitro and in vivo detection of NADP+. Biosens Bioelectron. 2016 Mar 15;77:901-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₉N₇O₁₇P₃

[ Molecular Weight ]:
744.41

[ PSA ]:
397.05000

[ LogP ]:
-7.30

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 50 mg/mL, clear, slightly yellow

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU3440000

CHEMICAL NAME :: Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-, hydroxide, 5',5'-ester with adenosine 2'- (dihydrogen phosphate) 5'-(trihydrogen pyrophosphate), inner salt

CAS REGISTRY NUMBER :: 53-59-8

BEILSTEIN REFERENCE NO. :: 3885115

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H28-N7-O17-P3

MOLECULAR WEIGHT :: 743.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3166 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 20,160,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1187 No. of Facilities: 58 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 332 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1187 No. of Facilities: 327 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 4926 (estimated) No. of Female Employees: 3928 (estimated)

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ RTECS ]:
UU3440000

[ HS Code ]:
2924199090

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%