ATR-IN-18

Names

[ CAS No. ]:
2766407-55-8

[ Name ]:
ATR-IN-18

Biological Activity

[Description]:

ATR-IN-18 (compound 2) is an orally active and potent ATR kinase inhibitor, with an IC50 of 0.69 nM. ATR-IN-18 shows antiproliferative activity in LoVo cells, with an IC50 of 37.34 nM. ATR-IN-18 has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR
Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR

[Target]

ATR:0.69 nM (IC50)


[References]

[1]. Xiaohui Liu, et al. Triheterocyclic derivative, and pharmaceutical composition and application thereof. WO2022078480A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H22F3N7O5S

[ Molecular Weight ]:
517.48

Related Compounds