VTP-27999

Names

[ Name ]:
VTP-27999

[Synonym ]:
Methyl (2-{(R)-(3-Chlorophenyl)[(3r)-1-({(2s)-2-(Methylamino)-3-[(3r)-Tetrahydro-2h-Pyran-3-Yl]propyl}carbamoyl)piperidin-3-Yl]methoxy}ethyl)carbamate
Methyl (2-((R)-(3-chlorophenyl)((R)-1-(((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)carbamoyl)piperidin-3-yl)methoxy)ethyl)carbamate
QC-4593
VTP-27999

Biological Activity

[Description]:

VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Renin

Research Areas >> Cardiovascular Disease

[References]

[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751

[2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.

[Related Small Molecules]

VTP 27999 trifluoroacetate | ACT 178882 | Handle region peptide, rat

Chemical & Physical Properties

[ Density]:
1.178g/cm3

[ Boiling Point ]:
703.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₆H₄₁ClN₄O₅

[ Molecular Weight ]:
525.08100

[ Flash Point ]:
379ºC

[ Exact Mass ]:
524.27700

[ PSA ]:
101.16000

[ LogP ]:
4.69060

[ Index of Refraction ]:
1.537

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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